This poster presentation explores the integration of artificial intelligence (AI) with instructional design principles, specifically L. Dee Fink’s framework for creating Significant Learning Experiences, in a Content and Language Integrated Learning (CLIL) program. The program is designed for Japanese university non-English majors. By leveraging generative AI in curriculum development, course design, materials creation, and assessment protocols, the program effectively addresses challenges in motivation and language acquisition among students with diverse proficiency levels. Key applications include AI-generated course materials tailored to disciplinary content, dynamic assessment tools that provide immediate and personalized feedback, and streamlined workflows for course planning and evaluation. Preliminary findings from the program’s implementation indicate increased learner engagement, improved comprehension of subject matter, and enhanced language proficiency. The presentation will provide practical insights for educators and researchers interested in harnessing generative AI to create meaningful and impactful CALL interventions, contributing to the broader discourse on CALL for All.